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CiwCiw 24.11.10 10:16

Fumaria densiflora DC. ve Fumaria officinalis L. Ekstrelerinin Brine Shrimp Yöntemiyle Sitotoksik Aktivite Çalışmaları
 
Toplam 2 eklenti bulunuyor.
Fumaria densiflora DC. ve Fumaria officinalis L. Ekstrelerinin Brine Shrimp Yöntemiyle Sitotoksik Aktivite Çalışmaları-Brine Shrimp Lethality Bioassay of Fumaria Densiflora Dc. and Fumaria Officinalis L. Extracts
Bağsaray (Burdur)' dan toplanan Fumaria officinalis' ten hazırlanan Herba Fumariae officinalis ve Kemalpaşa ilçesi Ulucak köyü (İzmir)' nden toplanan Fumaria densiflora DC. bitkisinden hazırlanan Herba Fumariae densiflorae droglarından hazırladığımız n-hegzan, etil asetat, etanol, metanol ve su ekstreleri üzerinde brine shrimp (Artemia salina) yöntemi ile sitotoksik aktivite tayini yapılmış ve LC50 değerleri hesaplanmıştır. F. densiflora DC.' dan elde edilen n-hegzan ve etil asetat ekstresi ile F. officinalis L.' den elde ettiğimiz n-hegzan ekstresi sitotoksik aktivite göstermiştir.

The cytotoxic activities of Herba Fumariae officinalis and Herba Fumariae densiflorae prepared from Fumaria officinalis L., growing wildly in Bağsaray (Burdur) and Fumaria densiflora DC., growing wildly in Kemalpaşa town Ulucak village (İzmir), respectively were determined. LC50 value of n-hexane, ethyl acetate, ethanol, methanol and water extracts of the plant materials were determined using brine shrimp (Artemia salina) lethality bioassay. The n-hexane and ethyl acetate extracts of Fumaria densiflora DC. and the n-hexane extract of F. officinalis L. showed cytotoxic activity against the brine shrimp.

Introduction
Fumaria species have been used in traditional medicine as anti¬hypertensives, diuretics, hepatoprotectants and laxatives (to treat gastrointestinal disorders), as well as in the treatment of raches and conjunctivitis12. The biological activity of Fumaria is mostly associated with the presence of isoquinoline alkaloids in the plant. In the last few years, a large number of scientific reports have been described the properties of Fumaria(3,4). There are seventeen wild-growing species belonging to this genus in Turkey56.
The extracts of F. officinalis L. have been used in traditional medicine for varied purposes treatment of digestive problems7, certain metabolic diseases8-11, liver disorders1213 and to purify blood14-16.
Phytochemical investigation revealed the presence of several alkaloids such as adlumidiceine, copticine, fumariline, perfumine, protopine17, fumaranine, fumaritine, paprafumicin and paprarine18. The plant has also been evaluated pharmacologically and shown to possess antihelmintic19, antipyretic20 and hypoglycemic21 properties.
Eklenti 54143

Tuğçe Fafal Erdoğan*
Ege University, Faculty of Pharmacy, Department of Pharmacagnasy, 35100 Bornova İzmir/Turkey.


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